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Crystal structure of the engineered neutralizing antibody M18

Analyse Crystal structure of the engineered neutralizing antibody M18 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ESV
Type: protein
Length: 455 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4…
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
F	Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker	protein	228	5% helix, 49% strand	—
G	Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker	protein	227	7% helix, 49% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	536	0.67	0.77	49	empty
2	79	0.40	0.78	24	empty
3	66	0.33	0.76	20	empty
4	65	0.31	0.75	18	empty

Interfaces

1 interface between chains.

F–G · 669 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3ESV · Crystal structure of the engineered neutralizing antibody M18 · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3ESV · PDBe 3ESV

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