Research workbench
Crystal structure of fragment 137 to 238 of the human ski-like protein
Analyse Crystal structure of fragment 137 to 238 of the human ski-like protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EQ5
- Type
- protein
- Length
- 1,156 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ski-like protein
- UniProt
- P12757
- Pockets
- 15 · best druggability 0.66
Structure
x-ray diffraction · 9 distinct chains · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ski-like protein | protein | 102 | 42% helix, 24% strand | P12757 |
| B, C | Ski-like protein | protein | 97 | 41% helix, 26% strand | P12757 |
| D | Ski-like protein | protein | 96 | 41% helix, 26% strand | P12757 |
| E | Ski-like protein | protein | 95 | 41% helix, 26% strand | P12757 |
| F | Ski-like protein | protein | 98 | 39% helix, 24% strand | P12757 |
| G | Ski-like protein | protein | 95 | 41% helix, 26% strand | P12757 |
| H | Ski-like protein | protein | 96 | 40% helix, 24% strand | P12757 |
| I, L | Ski-like protein | protein | 94 | 40% helix, 23% strand | P12757 |
| J, K | Ski-like protein | protein | 96 | 39% helix, 25% strand | P12757 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 503 | 0.66 | 0.77 | 49 | empty |
| 2 | 681 | 0.65 | 0.75 | 64 | empty |
| 3 | 509 | 0.65 | 0.77 | 73 | empty |
| 4 | 494 | 0.60 | 0.74 | 51 | empty |
| 5 | 306 | 0.58 | 0.77 | 42 | empty |
Interfaces
25 interfaces between chains.
- A–B · 665 Ų buried · 15 hydrogen bonds · protein-protein
- F–K · 616 Ų buried · 10 hydrogen bonds · protein-protein
- E–G · 606 Ų buried · 15 hydrogen bonds · protein-protein
- I–J · 605 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 599 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3EQ5 · Crystal structure of fragment 137 to 238 of the human Ski-like protein · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12757
- Elsewhere: RCSB PDB 3EQ5 · PDBe 3EQ5 · UniProt P12757
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.