Research workbench
Crystal structure of LAC031, an engineered anti-VLA1 Fab
Analyse Crystal structure of LAC031, an engineered anti-VLA1 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EOT
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab fragment, heavy chain; Fab fragment, light chain
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab fragment, heavy chain | protein | 212 | 7% helix, 54% strand | — |
| L | Fab fragment, light chain | protein | 214 | 7% helix, 51% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 584 | 0.62 | 0.74 | 51 | empty |
| 2 | 84 | 0.34 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- H–L · 1658 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 3EOT · Crystal structure of LAC031, an engineered anti-VLA1 Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3EOT · PDBe 3EOT
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