Research workbench

Substrate and inhibitor complexes of ribose 5-phosphate isomerase a from vibrio vulnificus YJ016

Analyse Substrate and inhibitor complexes of ribose 5-phosphate isomerase a from vibrio… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ENQ
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribose-5-phosphate isomerase a
EC: 5.3.1.6
UniProt: Q7MHL9
Pockets: 7 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ribose-5-phosphate isomerase a (EC 5.3.1.6)	protein	217	32% helix, 26% strand	Q7MHL9

Pockets

7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.41	0.80	19	empty
2	89	0.38	0.77	21	empty
3	71	0.38	0.78	15	empty
4	74	0.37	0.78	20	empty
5	80	0.36	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 1184 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

3ENQ · Substrate and inhibitor complexes of ribose 5-phosphate isomerase A from Vibrio… · the same entry in another collection · chain A against A, TM-score 1.00
Q7MHL9 · AlphaFold monomer V2.0 prediction for ribose-5-phosphate isomerase a (Q7MHL9) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7MHL9
Elsewhere: RCSB PDB 3ENQ · PDBe 3ENQ · UniProt Q7MHL9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.