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Crystal structure of human osteoclast stimulating factor

Analyse Crystal structure of human osteoclast stimulating factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3EHR
Type: protein
Length: 357 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Osteoclast-stimulating factor 1
UniProt: Q92882
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Osteoclast-stimulating factor 1	protein	178	38% helix, 16% strand	Q92882
B	Osteoclast-stimulating factor 1	protein	179	37% helix, 17% strand	Q92882

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.35	0.73	19	empty
2	66	0.30	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 361 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

3EHR · Crystal Structure of Human Osteoclast Stimulating Factor · the same entry in another collection · chain A against A, TM-score 1.00
Q92882 · AlphaFold monomer V2.0 prediction for osteoclast-stimulating factor 1 (Q92882) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92882
Elsewhere: RCSB PDB 3EHR · PDBe 3EHR · UniProt Q92882

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