Research workbench
Crystal structure of N-carbamoylsarcosine amidase from thermoplasma acidophilum
Analyse Crystal structure of N-carbamoylsarcosine amidase from thermoplasma acidophilum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EEF
- Type
- protein
- Length
- 346 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-carbamoylsarcosine amidase related protein
- EC
- 3.5.1.59
- UniProt
- Q9HKY9
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | N-carbamoylsarcosine amidase related protein (EC 3.5.1.59) | protein | 173 | 35% helix, 24% strand | Q9HKY9 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.62 | 0.89 | 19 | empty |
| 2 | 122 | 0.56 | 0.83 | 18 | empty |
| 3 | 126 | 0.56 | 0.82 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1121 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 3EEF · Crystal structure of N-carbamoylsarcosine amidase from thermoplasma acidophilum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HKY9
- Elsewhere: RCSB PDB 3EEF · PDBe 3EEF · UniProt Q9HKY9
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