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The crystal structure of the beta subunit of the DNA-directed RNA polymerase from vibrio cholerae O1 biovar eltor

Analyse The crystal structure of the beta subunit of the DNA-directed RNA polymerase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3E7H
Type
protein
Length
203 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA-directed RNA polymerase subunit beta
EC
2.7.7.6
UniProt
Q9KV30
Pockets
1 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 40% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA-directed RNA polymerase subunit beta (EC 2.7.7.6)protein10226% helix, 37% strandQ9KV30
BDNA-directed RNA polymerase subunit beta (EC 2.7.7.6)protein10126% helix, 43% strandQ9KV30

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12480.560.7736empty

Interfaces

1 interface between chains.

  • A–B · 326 Ų buried · 5 hydrogen bonds · protein-protein

Compared structures

  • 3E7H · The crystal structure of the beta subunit of the DNA-directed RNA polymerase from Vibrio… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9KV30 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (Q9KV30) · a predicted model of the same protein · chain B against A, TM-score 0.55

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