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Crystal structure of trmh family RNA methyltransferase from burkholderia pseudomallei

Analyse Crystal structure of trmh family RNA methyltransferase from burkholderia… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3E5Y
Type: protein
Length: 297 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trmh family RNA methyltransferase
UniProt: A4LJP7
Pockets: 4 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trmh family RNA methyltransferase	protein	156	39% helix, 19% strand	A4LJP7
B	Trmh family RNA methyltransferase	protein	141	35% helix, 21% strand	A4LJP7

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	282	0.64	0.81	29	empty
2	248	0.63	0.81	29	empty
3	163	0.49	0.77	25	empty
4	50	0.29	0.75	11	empty

Interfaces

1 interface between chains.

A–B · 1574 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

3E5Y · Crystal structure of TrmH family RNA methyltransferase from Burkholderia pseudomallei · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A4LJP7
Elsewhere: RCSB PDB 3E5Y · PDBe 3E5Y · UniProt A4LJP7

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