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Crystal structure of the hscarg Y81A mutant

Analyse Crystal structure of the hscarg Y81A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3E5M
Type: protein
Length: 589 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nmra-like family domain-containing protein 1
UniProt: Q9HBL8
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nmra-like family domain-containing protein 1	protein	294	43% helix, 15% strand	Q9HBL8
B	Nmra-like family domain-containing protein 1	protein	295	42% helix, 17% strand	Q9HBL8

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	319	0.69	0.83	32	empty
2	421	0.68	0.80	51	empty
3	144	0.56	0.82	20	empty

Interfaces

1 interface between chains.

A–B · 91 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3E5M · Crystal structure of the HSCARG Y81A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q9HBL8 · AlphaFold monomer V2.0 prediction for nmra-like family domain- containing protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HBL8
Elsewhere: RCSB PDB 3E5M · PDBe 3E5M · UniProt Q9HBL8

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