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Glycogen synthase kinase from leishmania major

Analyse Glycogen synthase kinase from leishmania major in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3E3P
Type: protein
Length: 674 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein kinase, putative glycogen synthase kinase
EC: 2.7.1.37
UniProt: Q4QE15
Pockets: 12 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein kinase, putative glycogen synthase kinase (EC 2.7.1.37)	protein	337	42% helix, 13% strand	Q4QE15
B	Protein kinase, putative glycogen synthase kinase (EC 2.7.1.37)	protein	337	41% helix, 14% strand	Q4QE15

Pockets

12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.74	0.99	17	empty
2	119	0.50	0.80	20	empty
3	123	0.49	0.79	18	empty
4	217	0.46	0.74	30	empty
5	87	0.40	0.78	21	empty

Interfaces

1 interface between chains.

A–B · 961 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

3E3P · Glycogen synthase kinase from Leishmania major · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4QE15
Elsewhere: RCSB PDB 3E3P · PDBe 3E3P · UniProt Q4QE15

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