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Structure of transcriptional factor alcr in complex with a target DNA

Analyse Structure of transcriptional factor alcr in complex with a target DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1F5E
Type
protein + DNA
Length
85 residues
Chains
3
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'-D(P*CP*GP*TP*GP*CP*GP*GP*AP*TP*C)-3'); DNA…
UniProt
P21228
Ligands
ZN

Structure

solution nmr · 3 distinct chains · 35% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA (5'-D(P*CP*GP*TP*GP*CP*GP*GP*AP*TP*C)-3')dna10——
BDNA (5'-D(P*GP*AP*TP*CP*CP*GP*CP*AP*CP*G)-3')dna10——
PEthanol regulon transcriptional factorprotein6535% helix, 0% strandP21228

Ligands and binding sites

  • ZN · Zinc ion · metal · 2 copies · chains P

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

  • B–P · 635 Ų buried · 33 hydrogen bonds · protein-nucleic
  • A–P · 525 Ų buried · 14 hydrogen bonds · protein-nucleic
  • A–B · 464 Ų buried · 39 hydrogen bonds · nucleic-nucleic

Compared structures

  • 1F5E · Structure of transcriptional factor alcr in complex with a target DNA · the same entry in another collection · chain A against A, TM-score 1.00
  • P21228 · AlphaFold monomer V2.0 prediction for regulatory protein alcr (P21228) · a predicted model of the same protein · chain P against A, TM-score 0.49

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