Research workbench
Crystal structure of S.POMBE ERF1/ERF3 complex
Analyse Crystal structure of S.POMBE ERF1/ERF3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3E20
- Type
- protein
- Length
- 1,656 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic peptide chain release factor GTP-binding subunit; Eukaryotic peptide chain…
- UniProt
- O74718, P79063
- Pockets
- 13 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 27% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, E, J | Eukaryotic peptide chain release factor GTP-binding subunit | protein | 196 | 2% helix, 55% strand | O74718 |
| C, B | Eukaryotic peptide chain release factor subunit 1 | protein | 261 | 39% helix, 16% strand | P79063 |
| H, K | Eukaryotic peptide chain release factor subunit 1 | protein | 175 | 35% helix, 15% strand | P79063 |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1105 | 0.75 | 0.78 | 114 | empty |
| 2 | 303 | 0.61 | 0.79 | 29 | empty |
| 3 | 249 | 0.59 | 0.79 | 21 | empty |
| 4 | 246 | 0.58 | 0.79 | 21 | empty |
| 5 | 269 | 0.56 | 0.77 | 27 | empty |
Interfaces
7 interfaces between chains.
- D–J · 560 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 560 Ų buried · 13 hydrogen bonds · protein-protein
- E–J · 549 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 523 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 522 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3E20 · Crystal structure of S.pombe eRF1/eRF3 complex · the same entry in another collection · chain K against K, TM-score 1.00
- O74718 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor GTP-binding… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74718
- Every structure of UniProt P79063
- Elsewhere: RCSB PDB 3E20 · PDBe 3E20 · UniProt O74718 · UniProt P79063
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