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Crystal structure of a type III polyketide synthase pksiiinc from neurospora crassa

Analyse Crystal structure of a type III polyketide synthase pksiiinc from neurospora… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3E1H
Type: protein
Length: 766 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative uncharacterized protein
EC: 2.3.1.74
UniProt: Q7S6N4
Pockets: 8 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Putative uncharacterized protein (EC 2.3.1.74)	protein	383	42% helix, 21% strand	Q7S6N4

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	356	0.80	0.89	59	empty
2	146	0.79	0.95	35	empty
3	101	0.66	0.90	35	empty
4	165	0.62	0.84	38	empty
5	58	0.46	0.84	16	empty

Interfaces

1 interface between chains.

A–B · 2464 Å² buried · 36 hydrogen bonds · protein-protein

Compared structures

3E1H · Crystal structure of a type III polyketide synthase PKSIIINc from Neurospora crassa · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7S6N4
Elsewhere: RCSB PDB 3E1H · PDBe 3E1H · UniProt Q7S6N4

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