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Crystal structure of a variable domain mutant of a T-cell receptor alpha chain

Analyse Crystal structure of a variable domain mutant of a T-cell receptor alpha chain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1AC6
Type: protein
Length: 220 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-cell receptor alpha
UniProt: P06323
Pockets: 1 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 60% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	T-cell receptor alpha	protein	110	3% helix, 60% strand	P06323

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.29	0.71	25	empty

Interfaces

1 interface between chains.

A–B · 623 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1AC6 · Crystal structure of a variable domain mutant of a T-cell receptor alpha chain · the same entry in another collection · chain A against A, TM-score 1.00
P06323 · AlphaFold monomer V2.0 prediction for T-cell receptor alpha chain V region ctl-F3 (P06323) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06323
Elsewhere: RCSB PDB 1AC6 · PDBe 1AC6 · UniProt P06323

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