Research workbench
Peptide-binding domain of heat shock 70 kda protein F, mitochondrial precursor, from caenorhabditis elegans.
Analyse Peptide-binding domain of heat shock 70 kda protein F, mitochondrial precursor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DQG
- Type
- protein
- Length
- 581 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein F
- UniProt
- P11141
- Pockets
- 4 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heat shock 70 kda protein F | protein | 148 | 14% helix, 45% strand | P11141 |
| C | Heat shock 70 kda protein F | protein | 138 | 11% helix, 48% strand | P11141 |
| D | Heat shock 70 kda protein F | protein | 147 | 14% helix, 45% strand | P11141 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 874 | 0.83 | 0.85 | 92 | empty |
| 2 | 124 | 0.55 | 0.83 | 26 | empty |
| 3 | 167 | 0.54 | 0.80 | 26 | empty |
| 4 | 75 | 0.31 | 0.74 | 16 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1776 Ų buried · 30 hydrogen bonds · protein-protein
- A–B · 1716 Ų buried · 27 hydrogen bonds · protein-protein
- B–D · 625 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 203 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 84 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3DQG · Peptide-binding domain of heat shock 70 kDa protein F, mitochondrial precursor, from… · the same entry in another collection · chain A against A, TM-score 1.00
- P11141 · AlphaFold monomer V2.0 prediction for heat shock protein HSP-6 (P11141) · a predicted model of the same protein · chain C against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11141
- Elsewhere: RCSB PDB 3DQG · PDBe 3DQG · UniProt P11141
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