Research workbench
Crystal structure of transcriptional regulator of the TETR/ACRR family (YP_290855.1) from thermobifida fusca yx-ER1 at 2.50 a resolution
Analyse Crystal structure of transcriptional regulator of the TETR/ACRR family… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DCF
- Type
- protein
- Length
- 368 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator of the TETR/ACRR family
- UniProt
- Q47L40
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator of the TETR/ACRR family | protein | 185 | 75% helix, 1% strand | Q47L40 |
| B | Transcriptional regulator of the TETR/ACRR family | protein | 183 | 76% helix, 1% strand | Q47L40 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.71 | 0.87 | 30 | empty |
| 2 | 271 | 0.71 | 0.85 | 39 | empty |
| 3 | 184 | 0.55 | 0.79 | 15 | empty |
| 4 | 173 | 0.55 | 0.79 | 16 | empty |
| 5 | 95 | 0.36 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2112 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 3DCF · Crystal structure of transcriptional regulator of the TetR/AcrR family (YP_290855.1) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q47L40
- Elsewhere: RCSB PDB 3DCF · PDBe 3DCF · UniProt Q47L40
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