Research workbench
Glyceraldehyde-3-phosphate dehydrogenase mutant with leu 33 replaced by thr, thr 34 replaced by gly, asp 36 replaced by gly, leu 187 replaced by ala, and pro 188 replaced by ser complexed with NAD+
Analyse Glyceraldehyde-3-phosphate dehydrogenase mutant with leu 33 replaced by thr… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DBV
- Type
- protein
- Length
- 1,336 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glyceraldehyde-3-phosphate dehydrogenase
- EC
- 1.2.1.12
- UniProt
- P00362
- Ligands
- NAD, SO4
- Pockets
- 15 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| O, P, Q, R | Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) | protein | 334 | 29% helix, 29% strand | P00362 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 4 copies · chains O, P, Q, R
- SO4 · Sulfate ion · ion · 8 copies · chains O, P, Q, R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.75 | 0.96 | 27 | empty |
| 2 | 572 | 0.71 | 0.80 | 59 | SO4, NAD |
| 3 | 556 | 0.71 | 0.80 | 67 | SO4, NAD |
| 4 | 620 | 0.68 | 0.77 | 66 | SO4, NAD |
| 5 | 635 | 0.67 | 0.77 | 63 | SO4, NAD |
Interfaces
6 interfaces between chains.
- Q–R · 2115 Ų buried · 29 hydrogen bonds · protein-protein
- O–P · 2108 Ų buried · 34 hydrogen bonds · protein-protein
- P–Q · 1428 Ų buried · 18 hydrogen bonds · protein-protein
- O–R · 1426 Ų buried · 18 hydrogen bonds · protein-protein
- P–R · 597 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3DBV · Glyceraldehyde-3-phosphate dehydrogenase mutant with leu 33 replaced by thr, thr 34… · the same entry in another collection · chain R against R, TM-score 1.00
- P00362 · AlphaFold monomer V2.0 prediction for glyceraldehyde-3-phosphate dehydrogenase (P00362) · a predicted model of the same protein · chain O against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00362
- Elsewhere: RCSB PDB 3DBV · PDBe 3DBV · UniProt P00362
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