Research workbench
Crystal structure of the N-terminal regulatory domains of the formin FHOD1
Analyse Crystal structure of the N-terminal regulatory domains of the formin FHOD1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DAD
- Type
- protein
- Length
- 635 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FH1/FH2 domain-containing protein 1
- UniProt
- Q9Y613
- Pockets
- 6 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | FH1/FH2 domain-containing protein 1 | protein | 324 | 61% helix, 8% strand | Q9Y613 |
| B | FH1/FH2 domain-containing protein 1 | protein | 311 | 61% helix, 5% strand | Q9Y613 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 260 | 0.56 | 0.77 | 29 | empty |
| 2 | 128 | 0.50 | 0.80 | 19 | empty |
| 3 | 113 | 0.49 | 0.80 | 18 | empty |
| 4 | 128 | 0.49 | 0.79 | 16 | empty |
| 5 | 132 | 0.47 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 562 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3DAD · Crystal structure of the N-terminal regulatory domains of the formin FHOD1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y613 · AlphaFold monomer V2.0 prediction for FH1/FH2 domain-containing protein 1 (Q9Y613) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y613
- Elsewhere: RCSB PDB 3DAD · PDBe 3DAD · UniProt Q9Y613
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