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Crystal structure of PIWI/ARGONAUTE/ZWILLE(PAZ) domain from thermococcus thioreducens

Analyse Crystal structure of PIWI/ARGONAUTE/ZWILLE(PAZ) domain from thermococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3DA5
Type: protein
Length: 242 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Argonaute
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Argonaute	protein	121	36% helix, 22% strand	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	510	0.68	0.79	43	empty

Interfaces

1 interface between chains.

A–B · 639 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

3DA5 · Crystal Structure of Piwi/Argonaute/Zwille(PAZ) domain from Thermococcus thioreducens · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3DA5 · PDBe 3DA5

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