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Crystal structure of acanthamoeba castellanii profilin II, cubic crystal form

Analyse Crystal structure of acanthamoeba castellanii profilin II, cubic crystal form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1F2K
Type: protein
Length: 250 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Profilin II
UniProt: P19984
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Profilin II	protein	125	37% helix, 33% strand	P19984

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	156	0.46	0.76	36	empty
2	78	0.37	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 439 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1F2K · Crystal structure of acanthamoeba castellanii profilin II, cubic crystal form · the same entry in another collection · chain A against A, TM-score 1.00
P19984 · AlphaFold monomer V2.0 prediction for profilin-2 (P19984) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19984
Elsewhere: RCSB PDB 1F2K · PDBe 1F2K · UniProt P19984

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