Research workbench
Crystal structure of the human FE65-PTB1 domain
Analyse Crystal structure of the human FE65-PTB1 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3D8D
- Type
- protein
- Length
- 278 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amyloid beta A4 precursor protein-binding family B member 1
- UniProt
- O00213
- Ligands
- HG
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Amyloid beta A4 precursor protein-binding family B member 1 | protein | 139 | 26% helix, 35% strand | O00213 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.58 | 0.78 | 39 | empty |
| 2 | 231 | 0.52 | 0.76 | 30 | HG |
| 3 | 118 | 0.42 | 0.77 | 23 | empty |
| 4 | 99 | 0.40 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 339 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3D8D · Crystal structure of the human Fe65-PTB1 domain · the same entry in another collection · chain A against A, TM-score 1.00
- O00213 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 precursor protein-binding family B… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00213
- Elsewhere: RCSB PDB 3D8D · PDBe 3D8D · UniProt O00213
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