Research workbench
Crystal structure of no complex of THR243ALA mutants of cytochrome P450NOR
Analyse Crystal structure of no complex of THR243ALA mutants of cytochrome P450NOR in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1F24
- Type
- protein
- Length
- 399 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nitric oxide reductase
- EC
- 1.7.99.7
- UniProt
- P23295
- Ligands
- HEM, NO
- Pockets
- 3 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nitric oxide reductase (EC 1.7.99.7) | protein | 399 | 53% helix, 10% strand | P23295 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- NO · Nitric oxide · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1090 | 0.80 | 0.82 | 85 | HEM, NO |
| 2 | 73 | 0.37 | 0.77 | 15 | empty |
| 3 | 52 | 0.29 | 0.75 | 12 | empty |
Compared structures
- 1F24 · Crystal structure of no complex of THR243ALA mutants of cytochrome P450NOR · the same entry in another collection · chain A against A, TM-score 1.00
- P23295 · AlphaFold monomer V2.0 prediction for NADP nitrous oxide-forming nitric oxide reductase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23295
- Elsewhere: RCSB PDB 1F24 · PDBe 1F24 · UniProt P23295
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