Research workbench
Structural and functional analysis of the E. COLI nusb-S10 transcription antitermination complex.
Analyse Structural and functional analysis of the E. COLI nusb-S10 transcription… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3D3C
- Type
- protein
- Length
- 673 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N utilization substance protein B; 30S ribosomal protein S10
- UniProt
- P0A780, P0A7R5
- Pockets
- 7 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | N utilization substance protein B | protein | 138 | 73% helix, 0% strand | P0A780 |
| J | 30S ribosomal protein S10 | protein | 85 | 31% helix, 41% strand | P0A7R5 |
| K, L | 30S ribosomal protein S10 | protein | 87 | 33% helix, 40% strand | P0A7R5 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 662 | 0.70 | 0.78 | 53 | empty |
| 2 | 72 | 0.58 | 0.89 | 17 | empty |
| 3 | 63 | 0.57 | 0.89 | 21 | empty |
| 4 | 139 | 0.46 | 0.76 | 14 | empty |
| 5 | 64 | 0.45 | 0.82 | 16 | empty |
Interfaces
9 interfaces between chains.
- C–L · 960 Ų buried · 11 hydrogen bonds · protein-protein
- B–K · 955 Ų buried · 14 hydrogen bonds · protein-protein
- A–J · 890 Ų buried · 15 hydrogen bonds · protein-protein
- A–K · 397 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 357 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3D3C · Structural and functional analysis of the E. coli NusB-S10 transcription antitermination… · the same entry in another collection · chain B against B, TM-score 1.00
- P0A780 · AlphaFold monomer V2.0 prediction for transcription antitermination protein nusb (P0A780) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A780
- Every structure of UniProt P0A7R5
- Elsewhere: RCSB PDB 3D3C · PDBe 3D3C · UniProt P0A780 · UniProt P0A7R5
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