Research workbench
Crystal structure of ligand-binding domain of estrogen- related receptor alpha (erralpha) in complex with the peroxisome proliferators-activated receptor coactivator- 1ALPHA BOX3 peptide (pgc-1ALPHA)
Analyse Crystal structure of ligand-binding domain of estrogen- related receptor alpha… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3D24
- Type
- protein
- Length
- 452 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Steroid hormone receptor ERR1; Peroxisome proliferator-activated receptor gamma…
- UniProt
- P11474, Q9UBK2
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 66% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Steroid hormone receptor ERR1 | protein | 209 | 67% helix, 4% strand | P11474 |
| B | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | protein | 13 | 54% helix, 0% strand | Q9UBK2 |
| C | Steroid hormone receptor ERR1 | protein | 216 | 67% helix, 4% strand | P11474 |
| D | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | protein | 14 | 50% helix, 0% strand | Q9UBK2 |
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 614 | 0.70 | 0.78 | 64 | empty |
| 2 | 152 | 0.62 | 0.85 | 20 | empty |
| 3 | 173 | 0.60 | 0.83 | 22 | empty |
| 4 | 163 | 0.59 | 0.83 | 23 | empty |
| 5 | 190 | 0.55 | 0.79 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1351 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 702 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 564 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3D24 · Crystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha)… · the same entry in another collection · chain D against D, TM-score 1.00
- P11474 · AlphaFold monomer V2.0 prediction for steroid hormone receptor ERR1 (P11474) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9UBK2 · AlphaFold monomer V2.0 prediction for peroxisome proliferator- activated receptor gamma… · a predicted model of the same protein · chain D against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11474
- Every structure of UniProt Q9UBK2
- Elsewhere: RCSB PDB 3D24 · PDBe 3D24 · UniProt P11474 · UniProt Q9UBK2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.