Research workbench
Crystal structure of the HIV-1 cross neutralizing monoclonal antibody 2F5 in complex with GP41 peptide lleldkwaslw
Analyse Crystal structure of the HIV-1 cross neutralizing monoclonal antibody 2F5 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3D0V
- Type
- protein
- Length
- 444 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2F5 Fab heavy chain; 2F5 Fab light chain; GP41 peptide lleldkwaslw
- UniProt
- Q7SVL4
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2F5 Fab heavy chain | protein | 214 | 6% helix, 51% strand | — |
| B | 2F5 Fab light chain | protein | 221 | 5% helix, 51% strand | — |
| C | GP41 peptide lleldkwaslw | protein | 9 | 0% helix, 22% strand | Q7SVL4 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 373 | 0.56 | 0.75 | 49 | empty |
| 2 | 64 | 0.30 | 0.74 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1781 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 362 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 344 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3D0V · Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SVL4
- Elsewhere: RCSB PDB 3D0V · PDBe 3D0V · UniProt Q7SVL4
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