Research workbench
Crystal structure of double mutant phenylalanine ammonia-lyase from anabaena variabilis
Analyse Crystal structure of double mutant phenylalanine ammonia-lyase from anabaena… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CZO
- Type
- protein
- Length
- 2,150 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidine ammonia-lyase
- EC
- 4.3.1.3
- UniProt
- Q3M5Z3
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 58% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Histidine ammonia-lyase (EC 4.3.1.3) | protein | 537 | 57% helix, 7% strand | Q3M5Z3 |
| B | Histidine ammonia-lyase (EC 4.3.1.3) | protein | 539 | 58% helix, 6% strand | Q3M5Z3 |
| D | Histidine ammonia-lyase (EC 4.3.1.3) | protein | 537 | 58% helix, 6% strand | Q3M5Z3 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.72 | 0.98 | 23 | empty |
| 2 | 771 | 0.69 | 0.76 | 78 | empty |
| 3 | 65 | 0.66 | 0.94 | 15 | empty |
| 4 | 69 | 0.58 | 0.89 | 16 | empty |
| 5 | 342 | 0.58 | 0.76 | 40 | empty |
Interfaces
4 interfaces between chains.
- A–B · 4406 Ų buried · 60 hydrogen bonds · protein-protein
- A–C · 455 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 418 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 305 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 64 modified (engineered, nonstandard).
Compared structures
- Q3M5Z3 · AlphaFold monomer V2.0 prediction for phenylalanine ammonia-lyase (Q3M5Z3) · a predicted model of the same protein · chain A against A, TM-score 1.00
- 3CZO · Crystal Structure of Double Mutant Phenylalanine Ammonia-Lyase From Anabaena Variabilis · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3M5Z3
- Elsewhere: RCSB PDB 3CZO · PDBe 3CZO · UniProt Q3M5Z3
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