Research workbench
Crystal structure of sifa and skip
Analyse Crystal structure of sifa and skip in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CXB
- Type
- protein
- Length
- 405 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein sifa; Pleckstrin homology domain-containing family M member 2
- UniProt
- Q56061, Q8IWE5
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein sifa | protein | 302 | 47% helix, 18% strand | Q56061 |
| B | Pleckstrin homology domain-containing family M member 2 | protein | 103 | 15% helix, 39% strand | Q8IWE5 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.60 | 0.83 | 19 | empty |
| 2 | 314 | 0.60 | 0.78 | 36 | empty |
| 3 | 82 | 0.43 | 0.80 | 14 | empty |
| 4 | 104 | 0.33 | 0.72 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 733 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3CXB · Crystal Structure of sifa and skip · the same entry in another collection · chain A against A, TM-score 1.00
- Q56061 · AlphaFold monomer V2.0 prediction for secreted effector protein sifa (Q56061) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q8IWE5 · AlphaFold monomer V2.0 prediction for pleckstrin homology domain- containing family M… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q56061
- Every structure of UniProt Q8IWE5
- Elsewhere: RCSB PDB 3CXB · PDBe 3CXB · UniProt Q56061 · UniProt Q8IWE5
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