Research workbench
Unphosphorylated mouse STAT3 core fragment
Analyse Unphosphorylated mouse STAT3 core fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CWG
- Type
- protein
- Length
- 1,008 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Signal transducer and activator of transcription 3
- UniProt
- P42227
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Signal transducer and activator of transcription 3 | protein | 501 | 39% helix, 15% strand | P42227 |
| B | Signal transducer and activator of transcription 3 | protein | 507 | 38% helix, 14% strand | P42227 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 938 | 0.75 | 0.78 | 92 | empty |
| 2 | 51 | 0.60 | 0.92 | 12 | empty |
| 3 | 272 | 0.56 | 0.77 | 36 | empty |
| 4 | 271 | 0.55 | 0.76 | 37 | empty |
| 5 | 129 | 0.50 | 0.80 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 521 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42227
- Elsewhere: RCSB PDB 3CWG · PDBe 3CWG · UniProt P42227
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