Research workbench

Structure of peroxisomal targeting signal 1 (PTS1) binding domain of trypanosoma brucei peroxin 5 (TBPEX5)COMPLEXED to PTS1 peptide (10- skl)

Analyse Structure of peroxisomal targeting signal 1 (PTS1) binding domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CVP
Type: protein
Length: 285 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome targeting signal 1 receptor PEX5; 10-skl PTS1 peptide ac-gtlsnraskl
UniProt: Q9U7C3
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome targeting signal 1 receptor PEX5	protein	279	75% helix, 0% strand	Q9U7C3
B	10-skl PTS1 peptide ac-gtlsnraskl	protein	6	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	201	0.56	0.79	36	empty
2	52	0.31	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 523 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3CVP · Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9U7C3
Elsewhere: RCSB PDB 3CVP · PDBe 3CVP · UniProt Q9U7C3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.