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Crystal structure of the carboxy terminus of HOMER3

Analyse Crystal structure of the carboxy terminus of HOMER3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CVF
Type: protein
Length: 286 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homer protein homolog 3
UniProt: Q9NSC5
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 3 distinct chains · 91% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Homer protein homolog 3	protein	70	91% helix, 0% strand	Q9NSC5
C	Homer protein homolog 3	protein	74	93% helix, 0% strand	Q9NSC5
D	Homer protein homolog 3	protein	72	89% helix, 0% strand	Q9NSC5

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.49	0.86	20	empty
2	128	0.46	0.78	19	empty

Interfaces

6 interfaces between chains.

C–D · 1085 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 1065 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 830 Å² buried · 5 hydrogen bonds · protein-protein
B–D · 829 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 604 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

3CVF · Crystal Structure of the carboxy terminus of Homer3 · the same entry in another collection · chain A against A, TM-score 1.00
Q9NSC5 · AlphaFold monomer V2.0 prediction for homer protein homolog 3 (Q9NSC5) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NSC5
Elsewhere: RCSB PDB 3CVF · PDBe 3CVF · UniProt Q9NSC5

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