Research workbench
Cre RECOMBINASE/DNA complex intermediate I
Analyse Cre RECOMBINASE/DNA complex intermediate I in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CRX
- Type
- protein + DNA
- Length
- 784 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA 35-mer; Cre recombinase
- UniProt
- P06956
- Pockets
- 12 · best druggability 0.85
Structure
x-ray diffraction · 5 distinct chains · 56% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | DNA 35-mer | dna | 35 | — | — |
| D | DNA 35-mer | dna | 34 | — | — |
| E | DNA 35-mer | dna | 35 | — | — |
| F | DNA 35-mer | dna | 34 | — | — |
| A, B | Cre recombinase | protein | 323 | 56% helix, 4% strand | P06956 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1046 | 0.85 | 0.87 | 107 | empty |
| 2 | 654 | 0.74 | 0.81 | 65 | empty |
| 3 | 68 | 0.72 | 0.96 | 11 | empty |
| 4 | 245 | 0.55 | 0.78 | 30 | empty |
| 5 | 222 | 0.52 | 0.77 | 22 | empty |
Interfaces
12 interfaces between chains.
- A–B · 1667 Ų buried · 30 hydrogen bonds · protein-protein
- C–B · 1461 Ų buried · 29 hydrogen bonds · protein-nucleic
- D–A · 1385 Ų buried · 26 hydrogen bonds · protein-nucleic
- D–B · 1277 Ų buried · 37 hydrogen bonds · protein-nucleic
- E–A · 1093 Ų buried · 17 hydrogen bonds · protein-nucleic
Compared structures
- 3CRX · Cre RECOMBINASE/DNA complex intermediate I · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06956
- Elsewhere: RCSB PDB 3CRX · PDBe 3CRX · UniProt P06956
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