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Crystal structure of the DNA-binding domain of the replication initiation protein E1 from papillomavirus

Analyse Crystal structure of the DNA-binding domain of the replication initiation… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1F08
Type: protein
Length: 293 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replication protein E1
UniProt: P03116
Ligands: BR
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replication protein E1	protein	148	39% helix, 30% strand	P03116
B	Replication protein E1	protein	145	40% helix, 30% strand	P03116

Ligands and binding sites

BR · Bromide ion · ion · 14 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.49	0.78	21	empty

Interfaces

1 interface between chains.

A–B · 363 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1F08 · Crystal structure of the DNA-binding domain of the replication initiation protein E1 from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03116
Elsewhere: RCSB PDB 1F08 · PDBe 1F08 · UniProt P03116

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