Research workbench
HIV neutralizing monoclonal antibody YZ23
Analyse HIV neutralizing monoclonal antibody YZ23 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CLE
- Type
- protein
- Length
- 430 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab light chain; Fab heavy chain
- Pockets
- 7 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Fab light chain | protein | 212 | 6% helix, 50% strand | — |
| H | Fab heavy chain | protein | 218 | 8% helix, 55% strand | — |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 440 | 0.59 | 0.74 | 58 | empty |
| 2 | 76 | 0.47 | 0.83 | 23 | empty |
| 3 | 134 | 0.46 | 0.77 | 23 | empty |
| 4 | 86 | 0.36 | 0.76 | 17 | empty |
| 5 | 75 | 0.30 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1725 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3CLE · HIV neutralizing monoclonal antibody YZ23 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3CLE · PDBe 3CLE
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.