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Anti-anti-idiotypic antibody against human angiotensin II, complex with human angiotensin II

Analyse Anti-anti-idiotypic antibody against human angiotensin II, complex with human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CK0
Type: protein
Length: 435 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (immunoglobulin; Protein (8-mer
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 3 distinct chains · 6% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Protein (immunoglobulin	protein	216	7% helix, 46% strand	—
H	Protein (immunoglobulin	protein	211	6% helix, 49% strand	—
P	Protein (8-mer	protein	8	0% helix, 0% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	501	0.59	0.74	61	empty
2	128	0.39	0.74	20	empty
3	72	0.31	0.74	17	empty

Interfaces

3 interfaces between chains.

L–H · 1592 Å² buried · 18 hydrogen bonds · protein-protein
L–P · 292 Å² buried · 4 hydrogen bonds · protein-protein
H–P · 240 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3CK0 · Anti-anti-idiotypic antibody against human angiotensin II, complex with human angiotensin… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3CK0 · PDBe 3CK0

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