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The kinase domain of escherichia COLI tyrosine kinase etk

Analyse The kinase domain of escherichia COLI tyrosine kinase etk in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CIO
Type: protein
Length: 510 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase etk
EC: 2.7.10.2
UniProt: P38134
Ligands: CL
Pockets: 6 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase etk (EC 2.7.10.2)	protein	255	36% helix, 16% strand	P38134
D	Tyrosine-protein kinase etk (EC 2.7.10.2)	protein	255	36% helix, 17% strand	P38134

Ligands and binding sites

CL · Chloride ion · ion · 3 copies · chains A, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.63	0.94	17	empty
2	436	0.61	0.76	45	empty
3	220	0.54	0.77	27	empty
4	232	0.51	0.76	41	CL
5	222	0.51	0.76	32	empty

Interfaces

1 interface between chains.

A–D · 879 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

3CIO · The kinase domain of Escherichia coli tyrosine kinase ETK · the same entry in another collection · chain A against A, TM-score 1.00
P38134 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase etk (P38134) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38134
Elsewhere: RCSB PDB 3CIO · PDBe 3CIO · UniProt P38134

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