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Crystal structure of salmonella sensor kinase phoq catalytic domain

Analyse Crystal structure of salmonella sensor kinase phoq catalytic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CGZ
Type: protein
Length: 411 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Virulence sensor histidine kinase phoq
EC: 2.7.13.3
UniProt: P14147
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 3 distinct chains · 33% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Virulence sensor histidine kinase phoq (EC 2.7.13.3)	protein	143	31% helix, 33% strand	P14147
B	Virulence sensor histidine kinase phoq (EC 2.7.13.3)	protein	136	33% helix, 29% strand	P14147
C	Virulence sensor histidine kinase phoq (EC 2.7.13.3)	protein	132	34% helix, 27% strand	P14147

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	137	0.42	0.75	28	empty
2	50	0.32	0.78	15	empty

Interfaces

2 interfaces between chains.

A–B · 1077 Å² buried · 15 hydrogen bonds · protein-protein
A–C · 944 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

3CGZ · Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14147
Elsewhere: RCSB PDB 3CGZ · PDBe 3CGZ · UniProt P14147

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