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Crystal structure of 2-phospho-(S)-lactate transferase from methanosarcina mazei. northeast structural genomics consortium target MAR46

Analyse Crystal structure of 2-phospho-(S)-lactate transferase from methanosarcina… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CGW
Type: protein
Length: 303 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: LPPG:FO 2-phospho-L-lactate transferase
EC: 2.7.8.-
UniProt: Q8PVT6
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	LPPG:FO 2-phospho-L-lactate transferase (EC 2.7.8.-)	protein	303	36% helix, 17% strand	Q8PVT6

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	564	0.70	0.79	56	empty
2	72	0.34	0.76	15	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

3CGW · Crystal structure of 2-phospho-(S)-lactate transferase from Methanosarcina mazei.… · the same entry in another collection · chain A against A, TM-score 1.00
Q8PVT6 · AlphaFold monomer V2.0 prediction for 2-phospho-L-lactate transferase (Q8PVT6) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8PVT6
Elsewhere: RCSB PDB 3CGW · PDBe 3CGW · UniProt Q8PVT6

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