Research workbench
High-resolution structure of blue fluorescent antibody EP2-19G2
Analyse High-resolution structure of blue fluorescent antibody EP2-19G2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CFC
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Blue fluorescent antibody EP2-19G2-IGG2B heavy chain; Blue fluorescent antibody…
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Blue fluorescent antibody EP2-19G2-IGG2B heavy chain | protein | 213 | 7% helix, 51% strand | — |
| L | Blue fluorescent antibody EP2-19G2-kappa light chain | protein | 219 | 5% helix, 49% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · chains H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.72 | 0.96 | 24 | empty |
| 2 | 743 | 0.66 | 0.75 | 72 | GOL |
| 3 | 73 | 0.49 | 0.84 | 22 | empty |
| 4 | 147 | 0.43 | 0.75 | 25 | empty |
| 5 | 116 | 0.38 | 0.74 | 24 | empty |
Interfaces
1 interface between chains.
- H–L · 1866 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 3CFC · High-resolution structure of blue fluorescent antibody EP2-19G2 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3CFC · PDBe 3CFC
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