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Crystal structure of L3MBTL2

Analyse Crystal structure of L3MBTL2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CEY
Type: protein
Length: 786 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: LETHAL(3)MALIGNANT brain tumor-like 2 protein
UniProt: Q969R5
Pockets: 6 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	LETHAL(3)MALIGNANT brain tumor-like 2 protein	protein	390	18% helix, 34% strand	Q969R5
B	LETHAL(3)MALIGNANT brain tumor-like 2 protein	protein	396	20% helix, 34% strand	Q969R5

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	892	0.83	0.85	90	empty
2	643	0.83	0.87	61	empty
3	98	0.45	0.79	22	empty
4	88	0.44	0.80	15	empty
5	101	0.38	0.75	25	empty

Interfaces

1 interface between chains.

A–B · 616 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3CEY · Crystal structure of L3MBTL2 · the same entry in another collection · chain A against A, TM-score 1.00
Q969R5 · AlphaFold monomer V2.0 prediction for LETHAL(3)MALIGNANT brain tumor- like protein 2… · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q969R5
Elsewhere: RCSB PDB 3CEY · PDBe 3CEY · UniProt Q969R5

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