Research workbench
The tpr domain of human kinesin light chain 2 (HKLC2)
Analyse The tpr domain of human kinesin light chain 2 (HKLC2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CEQ
- Type
- protein
- Length
- 519 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin light chain 2
- UniProt
- Q9H0B6
- Pockets
- 6 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin light chain 2 | protein | 250 | 74% helix, 0% strand | Q9H0B6 |
| B | Kinesin light chain 2 | protein | 269 | 74% helix, 0% strand | Q9H0B6 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 166 | 0.57 | 0.81 | 28 | empty |
| 2 | 103 | 0.49 | 0.81 | 21 | empty |
| 3 | 69 | 0.41 | 0.80 | 13 | empty |
| 4 | 87 | 0.40 | 0.78 | 15 | empty |
| 5 | 96 | 0.36 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1445 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H0B6
- Elsewhere: RCSB PDB 3CEQ · PDBe 3CEQ · UniProt Q9H0B6
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