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Crystal structure of reduced dsbl

Analyse Crystal structure of reduced dsbl in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3C7M
Type: protein
Length: 390 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: THIOL:DISULFIDE interchange protein dsba-like
UniProt: P0A4L7
Ligands: CD, CL
Pockets: 6 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	THIOL:DISULFIDE interchange protein dsba-like	protein	195	53% helix, 12% strand	P0A4L7

Ligands and binding sites

CD · Cadmium ion · metal · 6 copies · chains A, B
CL · Chloride ion · ion · 10 copies · chains A, B
PGE · Triethylene glycol · additive · chains A
PEG · Di(hydroxyethyl)ether · additive

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	231	0.51	0.76	32	empty
2	169	0.49	0.77	29	empty
3	188	0.48	0.76	30	empty
4	52	0.39	0.81	14	empty
5	101	0.34	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 840 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

3C7M · Crystal structure of reduced DsbL · the same entry in another collection · chain A against A, TM-score 1.00
P0A4L7 · AlphaFold monomer V2.0 prediction for THIOL:DISULFIDE interchange protein dsbl (P0A4L7) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A4L7
Elsewhere: RCSB PDB 3C7M · PDBe 3C7M · UniProt P0A4L7

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