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Crystal structure at 1.9A of the apo quinolinate phosphoribosyl transferase (BNA6) from saccharomyces cerevisiae

Analyse Crystal structure at 1.9A of the apo quinolinate phosphoribosyl transferase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3C2E
Type: protein
Length: 267 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nicotinate-nucleotide pyrophosphorylase
EC: 2.4.2.19
UniProt: P43619
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nicotinate-nucleotide pyrophosphorylase (EC 2.4.2.19)	protein	267	42% helix, 19% strand	P43619

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.57	0.85	17	empty
2	99	0.39	0.77	17	empty

Compared structures

3C2E · Crystal structure at 1.9A of the apo quinolinate phosphoribosyl transferase (BNA6) from… · the same entry in another collection · chain A against A, TM-score 1.00
P43619 · AlphaFold monomer V2.0 prediction for nicotinate-nucleotide pyrophosphorylase… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43619
Elsewhere: RCSB PDB 3C2E · PDBe 3C2E · UniProt P43619

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