Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-met in complex with a pyrrolotriazine based inhibitor

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 16% strand (DSSP).

Ligands and binding sites

• CKK · N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3C1X · Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor… · the same entry in another collection · chain A against A, TM-score 1.00
• P08581 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor receptor (P08581) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P08581
• Elsewhere: RCSB PDB 3C1X · PDBe 3C1X · UniProt P08581