Research workbench
Engineered human lipocalin 2 (LCN2) in complex with the extracellular domain of human ctla-4
Analyse Engineered human lipocalin 2 (LCN2) in complex with the extracellular domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BX7
- Type
- protein
- Length
- 293 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytotoxic T-lymphocyte-associated antigen 4; Engineered human lipocalin 2
- UniProt
- P16410
- Pockets
- 1 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Cytotoxic T-lymphocyte-associated antigen 4 | protein | 120 | 3% helix, 52% strand | P16410 |
| A | Engineered human lipocalin 2 | protein | 173 | 15% helix, 42% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 212 | 0.57 | 0.79 | 34 | empty |
Interfaces
1 interface between chains.
- C–A · 1235 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3BX7 · Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human… · the same entry in another collection · chain A against A, TM-score 1.00
- P16410 · AlphaFold monomer V2.0 prediction for cytotoxic T-lymphocyte protein 4 (P16410) · a predicted model of the same protein · chain C against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16410
- Elsewhere: RCSB PDB 3BX7 · PDBe 3BX7 · UniProt P16410
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