Research workbench
Crystal structure of TRF1 trfh domain and TIN2 peptide complex
Analyse Crystal structure of TRF1 trfh domain and TIN2 peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BQO
- Type
- protein
- Length
- 215 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomeric repeat-binding factor 1; TERF1-interacting nuclear factor 2
- UniProt
- P54274, Q9BSI4
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomeric repeat-binding factor 1 | protein | 202 | 73% helix, 1% strand | P54274 |
| B | TERF1-interacting nuclear factor 2 | protein | 13 | 0% helix, 15% strand | Q9BSI4 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.36 | 0.76 | 20 | empty |
| 2 | 53 | 0.27 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 933 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 3BQO · Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
- P54274 · AlphaFold monomer V2.0 prediction for telomeric repeat-binding factor 1 (P54274) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9BSI4 · AlphaFold monomer V2.0 prediction for TERF1-interacting nuclear factor 2 (Q9BSI4) · a predicted model of the same protein · chain B against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54274
- Every structure of UniProt Q9BSI4
- Elsewhere: RCSB PDB 3BQO · PDBe 3BQO · UniProt P54274 · UniProt Q9BSI4
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