Research workbench
Crystal structure of relb-rele antitoxin-toxin complex from methanococcus jannaschii
Analyse Crystal structure of relb-rele antitoxin-toxin complex from methanococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BPQ
- Type
- protein
- Length
- 251 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antitoxin RELB3; Toxin RELE3
- EC
- 3.1.-.-
- UniProt
- P0CL56, Q58503
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 4 distinct chains · 41% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antitoxin RELB3 | protein | 41 | 61% helix, 10% strand | P0CL56 |
| B | Toxin RELE3 (EC 3.1.-.-) | protein | 85 | 36% helix, 34% strand | Q58503 |
| C | Antitoxin RELB3 | protein | 39 | 49% helix, 13% strand | P0CL56 |
| D | Toxin RELE3 (EC 3.1.-.-) | protein | 86 | 34% helix, 34% strand | Q58503 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.39 | 0.78 | 12 | empty |
| 2 | 56 | 0.33 | 0.77 | 10 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1452 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1451 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 555 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 341 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 207 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3BPQ · Crystal Structure of RelB-RelE antitoxin-toxin complex from Methanococcus jannaschii · the same entry in another collection · chain D against D, TM-score 1.00
- Q58503 · AlphaFold monomer V2.0 prediction for toxin RELE3 (Q58503) · a predicted model of the same protein · chain B against A, TM-score 0.89
- P0CL56 · AlphaFold monomer V2.0 prediction for antitoxin RELB3 (P0CL56) · a predicted model of the same protein · chain C against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0CL56
- Every structure of UniProt Q58503
- Elsewhere: RCSB PDB 3BPQ · PDBe 3BPQ · UniProt P0CL56 · UniProt Q58503
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.