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Ribosome-secy complex

Analyse Ribosome-secy complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3BO0
Type
protein + RNA
Length
644 residues
Chains
7
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
23S ribosomal RNA; Preprotein translocase secy subunit; Preprotein translocase sece…
Pockets
11 · best druggability 0.77

Structure

electron microscopy · 7 distinct chains · 56% helix, 1% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
D23S ribosomal RNArna27——
E23S ribosomal RNArna27——
F23S ribosomal RNArna19——
G23S ribosomal RNArna32——
APreprotein translocase secy subunitprotein44254% helix, 1% strand—
BPreprotein translocase sece subunitprotein6574% helix, 0% strand—
CPreprotein translocase secg subunitprotein3253% helix, 3% strand—

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
18360.770.8184empty
28550.730.77100empty
33790.660.8043empty
43210.580.7636empty
51570.560.8020empty

Interfaces

9 interfaces between chains.

  • A–B · 1602 Ų buried · 9 hydrogen bonds · protein-protein
  • A–C · 1339 Ų buried · 11 hydrogen bonds · protein-protein
  • D–A · 120 Ų buried · 2 hydrogen bonds · protein-nucleic
  • G–A · 118 Ų buried · 0 hydrogen bonds · protein-nucleic
  • F–G · 107 Ų buried · 1 hydrogen bond · nucleic-nucleic

Compared structures

  • 3BO0 · Ribosome-SecY complex · the same entry in another collection · chain D against D, TM-score 1.00

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