Research workbench
Crystal structure of CJ0977, a SIGMA28-regulated virulence protein from campylobacter jejuni.
Analyse Crystal structure of CJ0977, a SIGMA28-regulated virulence protein from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BNV
- Type
- protein
- Length
- 1,105 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CJ0977
- UniProt
- Q0R4E3
- Pockets
- 12 · best druggability 0.70
Structure
x-ray diffraction · 6 distinct chains · 20% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | CJ0977 | protein | 142 | 22% helix, 40% strand | Q0R4E3 |
| B | CJ0977 | protein | 137 | 18% helix, 42% strand | Q0R4E3 |
| D | CJ0977 | protein | 143 | 24% helix, 40% strand | Q0R4E3 |
| F | CJ0977 | protein | 139 | 19% helix, 41% strand | Q0R4E3 |
| G | CJ0977 | protein | 130 | 17% helix, 44% strand | Q0R4E3 |
| H | CJ0977 | protein | 130 | 21% helix, 44% strand | Q0R4E3 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 861 | 0.70 | 0.75 | 70 | empty |
| 2 | 124 | 0.62 | 0.86 | 28 | empty |
| 3 | 357 | 0.58 | 0.76 | 45 | empty |
| 4 | 63 | 0.51 | 0.86 | 25 | empty |
| 5 | 99 | 0.51 | 0.83 | 26 | empty |
Interfaces
12 interfaces between chains.
- E–F · 1647 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1617 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1597 Ų buried · 17 hydrogen bonds · protein-protein
- G–H · 1530 Ų buried · 22 hydrogen bonds · protein-protein
- D–H · 745 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 3BNV · Crystal structure of Cj0977, a sigma28-regulated virulence protein from Campylobacter… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0R4E3
- Elsewhere: RCSB PDB 3BNV · PDBe 3BNV · UniProt Q0R4E3
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