Research workbench
Crystal structure of M11, the BCL-2 homolog of murine gamma- herpesvirus 68, complexed with mouse BECLIN1 (residues 106-124)
Analyse Crystal structure of M11, the BCL-2 homolog of murine gamma- herpesvirus 68… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BL2
- Type
- protein
- Length
- 300 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- V-BCL-2; Beclin-1
- UniProt
- P89884, O88597
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | V-BCL-2 | protein | 131 | 71% helix, 0% strand | P89884 |
| C, D | Beclin-1 | protein | 19 | 79% helix, 0% strand | O88597 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.36 | 0.80 | 16 | empty |
| 2 | 51 | 0.28 | 0.75 | 13 | empty |
Interfaces
6 interfaces between chains.
- A–C · 971 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 951 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 210 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 199 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 99 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3BL2 · Crystal Structure of M11, the BCL-2 Homolog of Murine Gamma-herpesvirus 68, Complexed… · the same entry in another collection · chain A against A, TM-score 1.00
- O88597 · AlphaFold monomer V2.0 prediction for beclin-1 (O88597) · a predicted model of the same protein · chain C against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P89884
- Every structure of UniProt O88597
- Elsewhere: RCSB PDB 3BL2 · PDBe 3BL2 · UniProt P89884 · UniProt O88597
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