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The structure of a dnab-like replicative helicase and its interactions with primase
Analyse The structure of a dnab-like replicative helicase and its interactions with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BGW
- Type
- protein
- Length
- 2,504 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dnab-like replicative helicase
- UniProt
- Q38152
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, E, F | Dnab-like replicative helicase | protein | 419 | 50% helix, 14% strand | Q38152 |
| D | Dnab-like replicative helicase | protein | 409 | 50% helix, 13% strand | Q38152 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 621 | 0.81 | 0.86 | 64 | empty |
| 2 | 716 | 0.80 | 0.84 | 70 | empty |
| 3 | 648 | 0.80 | 0.85 | 69 | empty |
| 4 | 872 | 0.77 | 0.81 | 73 | empty |
| 5 | 1070 | 0.76 | 0.79 | 105 | empty |
Interfaces
8 interfaces between chains.
- B–C · 3006 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2864 Ų buried · 29 hydrogen bonds · protein-protein
- E–F · 2737 Ų buried · 30 hydrogen bonds · protein-protein
- A–F · 2476 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 2424 Ų buried · 36 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3BGW · The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q38152
- Elsewhere: RCSB PDB 3BGW · PDBe 3BGW · UniProt Q38152
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